4-[[9-[(3s)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol

Name	CC-930
Synonyms	CC930 MCC930 CC 930 CC-930 TANZISERTIB Tanzisertib TANZISERTIB (CC-930) 4-[[9-[(3s)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol trans-4-[[9-[(3S)-Tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]cyclohexanol
CAS	899805-25-5

Molecular Formula	C21H23F3N6O2
Molar Mass	448.44
Density	1.63±0.1 g/cm3(Predicted)
Boling Point	626.4±65.0 °C(Predicted)
pKa	15.05±0.40(Predicted)
Storage Condition	-20℃
In vitro study	Human PMBC cells were able to inhibit the production of phosphorylation by phorbol-12-myristate-13-acetate (IC50=1 μm) by CC-930 after stimulation with c-Jun and phyto hemegutinin. CC-930 in 240 kinds of kinase, with significant selectivity. EGFR was the only non-MAP kinase that was inhibited by more than 50% at a concentration of 3 μm CC-930 (IC50=0.38 μm). At the concentration of 10 μm, the inhibitory effect of CC-930 on 75 receptors, ion channels and neurotransmitter transporters was not more than 50%. The inhibitory effect of CC-930 on CYP450 enzymes is not significant, and metabolism occurs under the action of CYP3A4 and 2D6.
In vivo study	In an acute PK-PD rat model of LPS-induced TNFα production, the in vivo TNFα production was reduced by 23% and 77% at 10 mg/kg and 30 mg/kg of CC-930, respectively, orally. CC-930 is well tolerated in vivo, and its effect is proportional to the dose.

Last Update：2024-01-02 23:10:35

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Product Name: CC-930 Visit Supplier Webpage Request for quotation
CAS: 899805-25-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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4-[[9-[(3s)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol Request for Quotation